Retinal and Choroidal Thickness in an Indigenous Population from Ghana: Comparison with Individuals with European or African Ancestry

PurposeTo evaluate the thickness of macular retina and central choroid in an indigenous population from Ghana, Africa to compare them with those measured among individuals European or African ancestry.DesignCross-sectional study, systematic review meta-analyses.ParticipantsForty-two healthy Ghanaians 37 ancestry, additional 1,427 subjects ancestry previously published studies.MethodsMacular retinal fovea, parafovea perifovea choroidal were extracted optical coherence tomography volume scans. Associations ethnicity, age sex assessed using mixed-effect regression models. Monte-Carlo simulations performed determine sensitivity significant associations potential confounders. Pooled estimates other groups generated through meta-analyses.Main Outcome MeasuresMacular thickness, their association sex.ResultsWhen adjusted for sex, are significantly thinner as compared (p < 0.001). A reduction is observed age, although this effect independent ethnicity. Meta-analyses indicate that differs markedly Americans reported populations.ConclusionsThe not only but also obtained Americans. Normative parameters determined may be sufficient describe populations.